Have you ever felt an unstoppable urge to urinate, a burning sensation, pain in the lower abdomen, or sometimes blood in the urine? That sounds like a classic UTI symptom. A UTI(urinary tract infection) is an infection of the Urinary system (Urethra, Kidneys, Bladder). One of the biggest challenges before the eyes of researchers is identifying the delayed onset of symptoms leading to complicated UTIs. Although UTIs are common, they can cause frustration, irritation, and discomfort, A sight of relief for millions of people who suffer from this every year as the FDA approves a new dynamic duo of Cefepime and enmetazobactam, gear up to understand this drug, its advantages, and its effects on the body in this blog.
Imagine E. coli (bacteria) as a little harmless friend who can turn into a foe as soon as it changes its position from the gut to the urinary system. The prevalence of E. coli in your Urinary system can be seen when E. coli crawls in your urethra and begins to spread in the bladder or from feces. E. coli has a specialized structure called fimbriae or pili which is like a tail allowing them to hold on to the cell linings of the urethra just like a little kid who is not ready to leave his mother’s hand on the first day of school. These bacteria grow exponentially and create a shield around themselves protecting them from the body’s immune system and other medicines. They release toxins irritating the bladder resulting in a burning sensation while urinating. In some severe cases, the bacteria travel to the kidneys causing a serious infection causing pyelonephritis) leading to fever, chills, and sometimes the release of blood in the urine.
Complicated UTIs can be excruciatingly painful and harder to treat as no one knows the number and type of bacteria causing this discomfort and because the bacteria become resistant to other drugs. The good news is that we can treat it better and faster with the help of Cefepime and enmetazobactam, which show synergistic effects (that is these medicines perform better when taken together). The real question is, there are already so many drugs present to treat this disease, what is so special about this drug? The answer to that is the drugs Cefepime and enmetazobactam can target a wide range of strains of gram-positive bacteria and gram-negative bacteria providing a quicker recovery to the patient which is very important in complicated UTIs. Studies show that the cure rate of this drug is better than some of the other drugs present. Cefepime, when enters the body, is very focused on killing the bacteria (target-specific nature) which inhibits cell wall synthesis in bacteria. Enmetazobactam is like an act protector for Cefepime by ensuring its safety from the enzyme beta-lactamase produced by certain harmful bacteria. Enmetazobactam ensures Cefepime functions effectively and eradicates bacteria from the body. Hence giving you relief from all the unwanted guests who were present in your Urinary tract.
Moving forward we can focus on conducting more clinical trials for dose optimization, cost-effective drugs that can block beta-lactamase production. The focus should also be on exploring new technologies for early UTI diagnosis.
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